Sarah M. Richardson-Burns: Postdoctoral Fellow, University
of Michigan Regenerative Sciences Training Program and Materials Science
and Engineering.
Research Summary
Current studies involve investigations on the interactions between
central nervous system (CNS)-derived cells and conducting polymers towards
development of highly biocompatible, bioactive biomaterials and microelectrodes
for long-term implantation in the CNS. Currently we are focusing on the characterization
of novel biocompatible conductive polymer coatings for implantable silicon
microelectrode array-based neural prosthetic devices as well as the development
of novel bioactive and adaptive conducting polymer microelectrodes intended
for long-term implantation in the CNS.
Education
1998: Bachelor of Science in Cell and Molecular Biology, University
of Michigan, Ann Arbor, MI.
2003: Doctor of Philosophy in Neuroscience, University of Colorado Health Sciences Center, Denver, CO.
Affiliations
Postdoctoral Fellow; University of Michigan Regenerative Sciences Training
Program
Current Postdoctoral Advisor: David C. Martin, Departments of Materials Science and Engineering, Biomedical Engineering, and Director of Macromolecular Science Program at The University of Michigan, Ann Arbor, MI.
Former Postdoctoral Advisor and Chair of Thesis Committee: Diego Restrepo, Departments of Cellular, Structural and Developmental Biology and Physiology and Director of Neuroscience Training Program at The University of Colorado Health Sciences Center, Denver CO.
Doctoral Thesis Advisor: Kenneth L. Tyler, Departments of Medicine, Neurology, Immunology, and Microbiology, and Neuroscience Training Program at The University of Colorado Health Sciences Center, Denver CO and Reuler-Lewin Endowed Chair of Neurology at the Denver Veterans Affairs Medical Center, Denver, CO.
Scientific Society Memberships
Society for Neuroscience
Society for Virology
Society for Biomaterials
Recent Abstracts
1. S. M. Richardson-Burns, J. L. Hendricks, L. Povlich, J. Yang, M. R. Abidian,
D. Kim, D.
C. Martin. Interactions Between Central Nervous System-derived Cells And The
Conductive
Polymer (poly)3,4-ethylenedioxythiophene (PEDOT). Abstract for the Annual Society
for
Biomaterials Conference in April 2005.
2. Andrew Sharp, Sarah Richardson-Burns, Wilder Doucette, Dudley Finch,
Ken Gall,
and Diego Restrepo. CNS biocompatibility of electrode neural probes is enhanced
by slow
insertion of the probe and use of polymer materials as opposed to silicon.
Abstract for the
Annual Society for Neuroscience conference in October, 2004.
Recent Publications
1. Sarah M. Richardson-Burns, Jeffrey L. Hendricks, Laura Povlich, Donghwan
(Richie)
Kim, Mohammad R. Abidian, Junyan Yang, and David C. Martin. Integration of
Neurons and
Glia with Novel Conductive Polymer-based Bioactive Electrodes: Formation of
Cell
Adhesions, Synapse-like Junctions and Neurite Networks. Manuscript in Preparation.
2. Sarah M. Richardson-Burns, Jerome Schaack, Robin Goody, Daniel A. Linseman,
Ron
J. Bouchard, Penny Clarke, and Kenneth L. Tyler. Virus-induced neuronal apoptosis
is
associated with convergent activation of Bid, Bim, and Bax and mitochondrial
release of
smac/DIABLO and omi/HtrA2. Manuscript submitted to Journal of Biological Chemistry
for review.
3. Shoshana Le, Sarah Richardson-Burns, Tracy Laessig, Ron Bouchard, Kenneth Tyler, Klaus Aktories, Holger Barth, Hinoshi Udo, Eric Kandel, Kim Heidenreich, and Daniel Linseman. Inhibition of Rac GTPase induces mitochondrial apoptotic signaling initiated by Bim in neurons. In press at Journal of Neurochemistry.
4 . Clarke P, Debiasi RL, Goody R, Hoyt CC, Richardson-Burns S, Tyler KL. Mechanisms of reovirus-induced cell death and tissue injury: role of apoptosis and virus-induced perturbation of host-cell signaling and transcription factor activation. Viral Immunol. 2005;18(1):89-115.
5. Clarke P, Richardson-Burns SM, DeBiasi RL, Tyler KL. Mechanisms of apoptosis during reovirus infection. Curr Top Microbiol Immunol. 2005;289:1-24.
6. Richardson-Burns SM, Tyler KL. Minocycline delays disease onset and mortality in reovirus encephalitis. Exp Neurol. 2005 Apr;192(2):331-9.
7. Hoyt CC, Richardson-Burns SM, Goody RJ, Robinson BA, Debiasi RL, Tyler KL. Nonstructural protein sigma1s is a determinant of reovirus virulence and influences the kinetics and severity of apoptosis induction in the heart and central nervous system. J Virol. 2005 Mar;79(5):2743-53.
8. Clarke P, Meintzer SM, Wang Y, Moffitt LA, Richardson-Burns SM, Johnson GL, Tyler KL. JNK regulates the release of proapoptotic mitochondrial factors in reovirus-infected cells. J Virol. 2004 Dec;78(23):13132-8.
9. Richardson-Burns SM, Tyler KL. Regional differences in viral growth and central nervous system injury correlate with apoptosis. J Virol. 2004 May;78(10):5466-75.
10. Edelmann KH, Richardson-Burns S, Alexopoulou L, Tyler KL, Flavell RA, Oldstone MB. Does Toll-like receptor 3 play a biological role in virus infections? Virology. 2004 May 1;322(2):231-8.
11. Richardson-Burns SM, Kleinschmidt-DeMasters BK, DeBiasi RL, Tyler KL. Progressive multifocal leukoencephalopathy and apoptosis of infected oligodendrocytes in the central nervous system of patients with and without AIDS. Arch Neurol. 2002 Dec;59(12):1930-6.
12. DeBiasi RL, Kleinschmidt-DeMasters BK, Richardson-Burns S, Tyler KL. Central nervous system apoptosis in human herpes simplex virus and cytomegalovirus encephalitis. J Infect Dis. 2002 Dec 1;186(11):1547-57.
13. Richardson-Burns SM, Kominsky DJ, Tyler KL. Reovirus-induced neuronal apoptosis is mediated by caspase 3 and is associated with the activation of death receptors. J Neurovirol. 2002 Oct;8(5):365-80.
14. Kantor L, Hewlett GH, Park YH, Richardson-Burns SM, Mellon MJ, Gnegy ME. Protein kinase C and intracellular calcium are required for amphetamine-mediated dopamine release via the norepinephrine transporter in undifferentiated PC12 cells. J Pharmacol Exp Ther. 2001 Jun;297(3):1016-24.
15. Richardson-Burns SM, Haroutunian V, Davis KL, Watson SJ, Meador-Woodruff JH. Metabotropic glutamate receptor mRNA expression in the schizophrenic thalamus. Biol Psychiatry. 2000 Jan 1;47(1):22-8.
16. Browman KE, Kantor L, Richardson S, Badiani A, Robinson TE, Gnegy ME.
Injection of the protein kinase C inhibitor Ro31-8220 into the nucleus accumbens
attenuates the acute response to amphetamine: tissue and behavioral studies.
Brain Res. 1998 Dec 14;814(1-2):112-9.
Personal Webpage
http://www.yofiproductions.com/sarah
